Correct!
2. Hypersensitivity pneumonitis

The thoracic CT scan shows small nodules that touch the pleura (Figure 3).

Figure 3. Small nodules are present that touch the pleura (arrows). There are also scattered areas of ground glass opacification.

Small nodules can be classified on CT scan as random, perilymphatic or centrilobular. Of these, centrilobular nodules do not touch the pleura unlike random and perilymphatic nodules. The most common cause of centrilobular nodules is hypersensitivity pneumonitis. Hematogenous metastasis and miliary tuberculosis usually present with random nodules while sarcoidosis and lymphangitic metastasis present with perilymphatic nodules.

The patient underwent bronchoscopy with transbronchial biopsy which was nondiagnostic.

What is the next step in the patient's work up? (Click on the correct answer to proceed to the third of five panels)

  1. CT/PET scan
  2. Mediastinoscopy
  3. Needle biopsy of the lung
  4. Serum angiotensin converting enzyme (ACE)
  5. Video-assisted thorascopic biopsy (VATS)

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