All Eosinophilia Is Not Asthma
Lewis J. Wesselius, MD
Departments of Pulmonary Medicine
Mayo Clinic Arizona
Scottsdale, AZ
History of Present Illness
A 73 year old man was seen with a one month history of shortness of breath. He dated this to an emergency room visit for an arm injury for which he had a DPT vaccination. Previously, he had been able to swim regularly, but he is now unable to swim due to worsening dyspnea. He also had some cough that was nonproductive.
PMH, SH and FH
He has a past medical history of coronary artery disease with prior stenting of his right and left anterior descending artery in 2010. He also has a history of hypertension, dysplipidemia, a carotid endarterectomy and a single seizure after a corneal transplant.
His present medications include:
- Atorvastatin
- Lisinopril
- Metoprolol
- Warfarin
He has a minimal smoking history and denied use of alcohol, drugs or unusual exposures.
Physical Examination
His vitals signs were normal and he was afebrile but he was receiving supplemental oxygen at 3 lpm.
Chest examination revealed bilateral crackles but no wheezes.
Cardiovascular examination showed a regular rhythm with a Grade 2/6 systolic ejection murmur.
He had no clubbing or edema.
The remainder of the physical examination was either normal or noncontributory.
Chest X-ray
His admission chest x-ray is shown in Figure 1.
Figure 1. Admission chest x-ray showing the PA (Panel A) and lateral (Panel B).
Which of the following are possible causes of the patient’s clinical picture?
- Coccidioidomycosis (Valley Fever)
- Allergic reaction to the DPT vaccination
- Pulmonary edema
- A + C
- All of the above
Reference as: Wesselius LJ. August 2012 pulmonary case of the month: all eosinophilia is not asthma. Southwest J Pulm Crit Care 2012;5:58-64. (Click here for a PDF version of the case presentation)